Design, Amino-Acid-Derived Analogues of FTY-720 and OSU-2S as PP2A Activators: Structure–Activity Relationships and Identification of Lead Compound XML-3D
Protein phosphatase 2A (PP2A) is a critical regulator of oncogenic signaling pathways, and pharmacological reactivation of PP2A through disruption of inhibitory protein interactions has emerged as a promising anticancer strategy. Although the sphingosine analogue FTY-720 and its derivative OSU-2S can restore PP2A activ...
Rui Yang, N. Srour, Pankajavalli Thirugnanasambandam et al.
· bioRxiv · 0 citations