Molecular Mechanisms and Therapeutic Targeting of the Macrophage Metabolic-Epigenetic Interaction Network in Chronic Obstructive Pulmonary Disease
This review outlines the biochemical components of this crosstalk, linking shifts in glucose, lipid, and glutamine metabolism to chromatin remodeling events, and details four major molecular axes: α-ketoglutarate-dependent DNA methylation, NAD⁺/SIRT1-mediated deacetylation, the acetyl-CoA-fueled histone acetylation fee...