Review

Molecular Mechanisms and Therapeutic Targeting of the Macrophage Metabolic-Epigenetic Interaction Network in Chronic Obstructive Pulmonary Disease

Qi Liu Wei-Ying Liu

Aug 2026 · Cell Biochemistry and Biophysics · Vol 84, pp. 3231 - 3244 · 0 citations · 96 references

Medicine

TL;DR

This review outlines the biochemical components of this crosstalk, linking shifts in glucose, lipid, and glutamine metabolism to chromatin remodeling events, and details four major molecular axes: α-ketoglutarate-dependent DNA methylation, NAD⁺/SIRT1-mediated deacetylation, the acetyl-CoA-fueled histone acetylation feedback loop, and the regulatory influence of non-coding RNAs (ncRNAs).

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