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Author

Qin Zhang

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Aug 2026

USP16 functions as a novel deubiquitinase of YAP and a therapeutic target of isorhamnetin in gastric cancer.

A previously unidentified USP16-YAP regulatory axis that drives gastric cancer progression is revealed and USP16 is demonstrated as a therapeutic target of ISO, providing a mechanistic basis for the development of ISO-derived strategies targeting YAP stabilization in gastric cancer.

Yehua Li, S. Ren, Qin Zhang et al. · 0 citations
Open access Sep 2026

DFRL-Mol: a dual-stage framework of reinforcement learning for multi-scenario molecule optimization

Comparisons with state-of-the-art methods demonstrate the enhanced performance of DFRL-Mol in multiple scenarios of molecule optimization, including SO optimization, substructure-constrained (SC) SO optimization, MO optimization, and MO molecule generation.

Zhen-Yi Wu, Peng-Cheng Zhao, Jia-Ning Li et al. · 0 citations
Review Jul 2026

Three-Dimensional Bioprinting-Enabled Organoids for Engineering the Tumor Microenvironment.

Three-dimensional bioprinting technology has emerged as a promising engineering tool for constructing TME-like models with controlled spatial architecture, tunable matrix properties, and programmable multicellular organization and practical directions for developing more physiologically relevant platforms for cancer re...

Yehua Li, Jia-Le Shi, Qin Zhang et al. · 0 citations

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