USP16 functions as a novel deubiquitinase of YAP and a therapeutic target of isorhamnetin in gastric cancer.

Yehua Li S. Ren Qin Zhang Huan-Huan Chen Xiang Ji Jia-Le Shi Jin-Bo Yang Bi-Qiang Sun Fang-Rui Bai Hai Huang Shen’ao Zhou

Aug 2026 · Phytomedicine · Vol 161, pp. 158717 · 0 citations

Medicine

TL;DR

A previously unidentified USP16-YAP regulatory axis that drives gastric cancer progression is revealed and USP16 is demonstrated as a therapeutic target of ISO, providing a mechanistic basis for the development of ISO-derived strategies targeting YAP stabilization in gastric cancer.

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