Highlights • RSPO1 is upregulated in cervical cancer.• RSPO1 promotes proliferation, migration, invasion, and tumorigenesis in vitro/vivo.• RSPO1 activates EGFR/Src/ERK/AKT axis via LGR4 in cervical cancer.• RSPO1-LGR4 stabilizes EGFR by blocking c-Cbl-mediated ubiquitination/degradation.
Li-Ting Lu, Xi-Duan Wei, Sai Liu et al.· Neoplasia· 0 citations
The nervous and immune systems interact to form a complex network that sustains homeostasis and finely tunes immune responses. These interactions significantly influence the pathogenesis and progression of various diseases, such as tumors, immune-related disorders, and infections. Consequently, these interactions have...
Qing-Yuan Zhuang, Si-Wei Zhang, Zhi-Ming Shao et al.· Signal Transduction and Targ...· 0 citations
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