Open access
RSPO1–LGR4 axis drives cervical cancer progression via activation of the EGFR/Src/ERK/AKT signaling pathway
Li-Ting Lu
Xi-Duan Wei
Sai Liu
Su-Ting Lei
Qing Ji
Xiao-Qiang Wu
Qing-Yuan Zhuang
Ru-Lu Pan
Chen Zheng
Yang-Yang Fu
Xin-Cheng Lu
Medicine
Abstract
Highlights • RSPO1 is upregulated in cervical cancer.• RSPO1 promotes proliferation, migration, invasion, and tumorigenesis in vitro/vivo.• RSPO1 activates EGFR/Src/ERK/AKT axis via LGR4 in cervical cancer.• RSPO1-LGR4 stabilizes EGFR by blocking c-Cbl-mediated ubiquitination/degradation.