Open access
Oct 2026
RSPO1–LGR4 axis drives cervical cancer progression via activation of the EGFR/Src/ERK/AKT signaling pathway
Highlights • RSPO1 is upregulated in cervical cancer.• RSPO1 promotes proliferation, migration, invasion, and tumorigenesis in vitro/vivo.• RSPO1 activates EGFR/Src/ERK/AKT axis via LGR4 in cervical cancer.• RSPO1-LGR4 stabilizes EGFR by blocking c-Cbl-mediated ubiquitination/degradation.
Li-Ting Lu, Xi-Duan Wei, Sai Liu et al.
· Neoplasia · 0 citations