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Author

Xi-Duan Wei

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Open access Oct 2026

RSPO1–LGR4 axis drives cervical cancer progression via activation of the EGFR/Src/ERK/AKT signaling pathway

Highlights • RSPO1 is upregulated in cervical cancer.• RSPO1 promotes proliferation, migration, invasion, and tumorigenesis in vitro/vivo.• RSPO1 activates EGFR/Src/ERK/AKT axis via LGR4 in cervical cancer.• RSPO1-LGR4 stabilizes EGFR by blocking c-Cbl-mediated ubiquitination/degradation.

Li-Ting Lu, Xi-Duan Wei, Sai Liu et al. · 0 citations
Open access Jul 2026

NOD1/2 signaling in macrophages drives adaptive immune resistance in cancer

NOD1/2 is defined as a novel innate immune checkpoint that orchestrates therapy-induced adaptive resistance and highlight this pathway as a promising target to overcome treatment resistance in refractory cancers.

Xi-Duan Wei, Li Yang, Yuting Wang et al. · 0 citations

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