Discoid lupus erythematosus (DLE) is a chronic cutaneous subtype of lupus erythematosus characterized by inflammatory lesions that are highly susceptible to secondary infection, particularly in immunocompromised individuals. Cutaneous fungal granulomas caused by Candida tropicalis and superimposed on pre-existing DLE l...
Ling-Ling Dong, Ting Zhang, Tong Hua et al.· Frontiers in Medicine· 0 citations
This work identifies Treg destabilization as a staged and branching differentiation process rather than an abrupt loss of lineage identity, and establishes a framework for Treg destabilization during atherosclerosis.
Qingkang Lyu, Yan Wang, Anusha Bellapu et al.· bioRxiv· 0 citations
To better understand the factors driving Treg to exTreg conversion, transcriptomes of Treg subsets expressing varied levels of CD25 and FOXP3 are analyzed in human peripheral blood CD4+ T cells.
Smriti Parashar, P. Roy, Mohammad Oliaeimotlagh et al.· Journal of Immunology· 0 citations
Atherosclerosis is an immune-mediated disease in which regulatory T cells (Tregs) can lose lineage stability and convert into pro-inflammatory effector states (“exTregs”) that may accelerate plaque progression. However, the diversity, lineage relationships, and pathogenic roles of exTreg subsets in cardiovascular...
Qingkang Lyu, Anusha Bellapu, Polina Bombina et al.· Journal of Immunology· 0 citations
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