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Atherosclerosis destabilizes regulatory T cells (Tregs) resulting in multiple families of exTregs

Qingkang Lyu Yan Wang Anusha Bellapu Polina Bombina Sunil Kumar Lauren Fogel Smriti Parashar Kun-Zhe Dong Jiang Zhou Devadatta Gosavi Mikhail Fomin Klaus Ley

Jul 2026 · bioRxiv · 0 citations · 53 references

Biology

TL;DR

This work identifies Treg destabilization as a staged and branching differentiation process rather than an abrupt loss of lineage identity, and establishes a framework for Treg destabilization during atherosclerosis.

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