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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

R. Beroukhim

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Open access Aug 2026

O-mannosylation and furin processing are critical maturation events for the KIAA1549 protein implicated in pediatric pilocytic astrocytomas.

The gene fusion KIAA1549::BRAF is a common oncogenic driver in pediatric pilocytic astrocytoma. The chimeric fusion protein that comprises most of the type 1 transmembrane KIAA1549 protein fused in its C-terminal cytosolic domain to the truncated BRAF oncogene without its N-terminal autoinhibitory domains. KIAA1549 has...

Gloria Kyrila, Serpil Ahmed, Anna Borgenvik et al. · 0 citations
Open access Aug 2026

A compendium of next-generation patient-derived models for diverse cancers

The development of new therapeutics and the validation of pathogenetic cancer mechanisms require representative laboratory models1,2. However, existing collections represent only a fraction of the diversity observed in human cancer2, 3–4. Recent technologies have enabled efficient in vitro model derivation (for example...

Dina Elharouni, Mushriq Al-Jazrawe, Seongmin Choi et al. · 3 citations
Open access Aug 2026

Splicing genes as main targets of differential splicing.

Splicing of transcripts via the spliceosome machinery is a complex process involving a multitude of proteins and short noncoding RNAs. In addition to full-length transcripts with all exons in the genomically encoded order, alternatively spliced transcripts can also be produced through alternative splicing of pre-mRNA....

T. Tengs, T. LaFramboise, Yossef Baidi et al. · 0 citations

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