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Author

R. D. de Groot

2 papers indexed here

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coronavirus hemagglutinin-esterase receptor-binding site: a major shift in ligand specificity through modest changes in architecture

The crystal structure of the lectin domain of mouse hepatitis virus (MHV) strain S HE is presented, resolved both in its native state and in complex with a receptor analogue, illustrating the ease with which viruses can change receptor-binding specificity.

M. Langereis, Q. Zeng, B. Heesters et al. · 0 citations
Open access Aug 2026

Spike and host glycan determinants of HKU1 airway tropism

It is shown that spikes from both serotypes of HKU1 preferentially bind 9-O-acetylated α2,8-linked disialosides, and molecular dynamics simulations indicated that membrane-embedded GT3, but not GD3, presents its glycan chain in a geometry compatible with S1A-mediated engagement.

Robert Creutznacher, Louisa Elizabeth Wallace, Oliver J. Debski-Antoniak et al. · 0 citations

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