The crystal structure of the lectin domain of mouse hepatitis virus (MHV) strain S HE is presented, resolved both in its native state and in complex with a receptor analogue, illustrating the ease with which viruses can change receptor-binding specificity.
Enveloped viruses possess a membrane composed of a complex mixture of host‐derived lipids, glycolipids, and viral glycoproteins, which play a critical role in host–virus interactions. Viral glycoproteins can be detected by a range of immune lectins, thereby modulating and sometimes subverting the host immune responses...
Vladimir Bokun, Wen-Gang Chai, Robert L. Buchanan et al.· European Journal of Immunolo...· 0 citations
Plasmodium falciparum is the only human-infective species within the Laverania subgenus. In order for Plasmodium falciparum merozoites to invade erythrocytes, parasite ligands interact with a number of erythrocyte surface proteins, several of which are modified with sialic acids. These sialic acids differ between human...
Patrycja Burzyńska, Eleanor Silvester, Alison Kemp et al.· Molecular and biochemical pa...· 0 citations
HRBD demonstrated potent and broad-spectrum inhibition against Pangolin-CoV, SARS-CoV, SARS-CoV, SARS-CoV-2, and its variants, lowering the half-maximal inhibitory concentration (IC50) by approximately 1000-fold compared to the monomeric RBD.
Jintao Zou, Lingyu Su, Jian-Sheng Lu et al.· Antiviral Research· 0 citations
Cryo-electron microscopy structures of yellow fever virus (YFV) E bound to low-density lipoprotein receptor-related protein 4 (LRP4) and LRP8, and of tick-borne encephalitis virus (TBEV) E bound to LRP8 are determined, identifying key determinants of receptor specificity for these two orthoflaviviruses.
Chenggong Ji, Laurentia V. Tjang, Biswajit Das et al.· bioRxiv· 0 citations
Heparan sulfate (HS) is a key host-factor mediator of SARS-CoV-2 attachment and an attractive target for antiviral intervention, yet the synthesis of structurally defined HS oligosaccharides remains challenging. Here, we show that a defined HS hexasaccharide, heparin-dp6, efficiently inhibits RBD-ACE2 binding and exhib...
It is shown that IP6 binding is conserved across diverse retroviruses but occurs through distinct capsid sites and mechanisms, and influences viral behaviour.
J. Klarhof, D. Mallery, James C. V. Stacey et al.· Nature Communications· 0 citations
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