Author

R. Holewinski

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Open access Sep 2026

CD38 inhibition preserves adult human hematopoietic stem cells

In humans, long-term hematopoietic stem cells (LT-HSCs) are enriched within the CD34⁺CD38 low fraction in vivo, and CD38 abundance typically rises with lineage commitment, suggesting that CD38 may function as a negative regulator of stem cell function. Here, we show that pharmacologic CD38 inhibition with 78c dur...

Jian-Yi Ding, Daisuke Araki, Yong-Qin Li et al. · Cell Death & Disease · 0 citations

#protein folding Open access Aug 2026

Phosphorylation Protects Oncogenic RAS from LZTR1-Mediated Degradation.

PAK1 and PAK2 shielded RAS from LZTR1-dependent degradation by phosphorylating T148, and inhibiting PAK1/2 activity improved RAS-directed therapy, revealing a regulatory circuit governing RAS stability that is preferentially active in blood cancers and potentially druggable.

Lin Zhang, A. Bolomsky, Omar S. Al-Odat et al. · Blood Cancer Discovery · 0 citations