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R. Kingston

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Oct 2026

Nucleoside analogs containing an imino-ribitol sugar exhibit a distinctive pattern of interference with RNA synthesis by the Dengue virus polymerase.

Iminovirs are antiviral nucleoside analogs in which the naturally occurring ribose sugar is replaced by an imino-ribitol group, linked to the base by a non-native carbon-carbon bond. The prototypical iminovir is galidesivir, an adenosine analog that inhibits replication of a wide range of RNA viruses. Initial investiga...

S. Deshpande, Anthony J. B. van Hameren, James M. Wood et al. · 0 citations
#gene editing Open access Aug 2026

A PepFect14 analog improves non‐viral CRISPR delivery in primary human cells to facilitate genome editing and repair

A PepFect14 analog is employed to deliver high-fidelity Cas9-ribonucleoproteins and non-viral repair templates into primary human skin cells to mediate gene editing and repair targeting genes underlying the group of genetic skin blistering disorders epidermolysis bullosa (EB).

Alex du Rand, Courtney Masterson, Daniel J. Verdon et al. · 0 citations

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