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Cullin 3 ubiquitin ligase regulates redox defense and metabolic programs in proximal tubule cells.
BACKGROUND Chronic kidney disease (CKD) is characterized by proximal tubule (PT) stress, oxidative injury, and metabolic dysfunction. Human kidney single-nucleus RNA-sequencing (snRNA-seq) identified enrichment of ubiquitin-dependent protein catabolic processes in injured PT cells, suggesting activation of the ubiquiti...