Chitosan-Coated PLGA Nanoparticles Embedded Thermosensitive Intranasal In-Situ Gel of Withaferin-A for Enhanced Brain Targeting in Alzheimer’s Disease: Formulation, Optimization and PK-PD Evaluation
Treatment of chitosan-coated poly(lactic-co-glycolic acid) nanoparticles incorporated into a thermosensitive intranasal gel for enhancing brain exposure and the therapeutic potential of Withaferin-A in AD supports the potential of the CPNPs-loaded thermosensitive intranasal gel.