TL;DR
Treatment of chitosan-coated poly(lactic-co-glycolic acid) nanoparticles incorporated into a thermosensitive intranasal gel for enhancing brain exposure and the therapeutic potential of Withaferin-A in AD supports the potential of the CPNPs-loaded thermosensitive intranasal gel.
Nanoemulsions, which are nanostructured and colloidally stabilized materials, have emerged as a promising approach for drug delivery. A major challenge in treating Alzheimer's disease (AD) is overcoming the blood-brain barrier (BBB) to deliver therapeutic agents effectively to the brain. The goal of this study was to d...
These findings provide pharmacokinetic proof-of-concept supporting further investigation of this intranasal formulation for CNS delivery of DMF, and show high biocompatibility and reciprocal enhancement of stability.
The developed chitosan-coated Eudragit® S100 nanoparticle system represents a promising platform for sustained, colon-targeted oral delivery of HSP and other poorly bioavailable bioactive compounds.
Lamotrigine-loaded chitosan-sodium alginate polymeric nanoparticle system optimized by BoxBehnken Design demonstrated improved release control, enhanced pharmacokinetic parameters, and superior anticonvulsant activity in vivo, supporting their potential as a sustained-release system for epilepsy management.
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