Author

R. Zweigerdt

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Open access Oct 2026

Transient Vascular Cell Integration and Intrinsic Media-Stimulated Endothelial Activation Reveal Diabetic Retinopathy Signatures in Human Retinal Organoids

Retinal organoids (ROs) model human retinogenesis but remain avascular and lack immune components, limiting their utility for studying vascular retinopathies. We generated vascular organoids (VOrs) from human pluripotent stem cells and evaluated their integration into developing ROs. Dissociated VOr cells (day 12 or da...

Rosalia Tsikandelova, R. Schettler, Matthew D. Teasdale et al. · bioRxiv · 0 citations

Open access Sep 2026

Structural and functional remodeling of large-scale cardiac tubes.

The functionality of tissue-engineered cardiac constructs using human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) is challenged by the cells' immature state. To promote cell and tissue maturation, co-culture approaches, mechanical, electrical and topographical stimuli have been applied. Here, large...

Sara Szadocka, Jana Teske, A. Franke et al. · Biofabrication · 0 citations

#protein folding Open access Aug 2026

Human iPSC-cardiomyocyte-aggregate cell therapy in non-human primates and correlation of heart recovery with contractile and electrophysiological cardiomyocyte properties

This study demonstrates the successful production and injection of human induced pluripotent stem cell cardiomyocyte aggregates into infarcted cynomolgus monkey hearts, resulting in substantial, structured human grafts three months after cell transplantation, and uncoupling of cardiomyocyte production from transplantat...

I. Gruh, Andreas Martens, S. Cebotari et al. · Nature Communications · 0 citations