Author

Rachana Sapkota

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Open access Sep 2026

Spray Freeze Drying for Solid Formulations of RNA Lipid Nanoparticles

Spray-freeze drying (SFD) is a promising drying technique for stabilizing RNA lipid nanoparticles (RNA-LNPs) by converting them into solid-state formulations. This study examined the impact of the SFD process and the widely utilized stabilizing disaccharides, such as sucrose and trehalose, on the major properties (e.g....

K. Arte, Rachana Sapkota, Chanakya D. Patil et al. · AAPS PharmSciTech · 0 citations

Open access Aug 2026

Investigating the impact of trehalose crystallization on protein aggregation in lyophilized formulations

Trehalose is a commonly used lyoprotectant for stabilizing proteins in lyophilized formulations. Its physical state plays a critical role in maintaining both the physical and chemical stability of proteins. In this study, three types of protein/trehalose systems were studied to understand the impact of trehalose crysta...

Rachana Sapkota, Isabella Perez Mejia, Cole W. Tower et al. · AAPS Open · 0 citations

#protein folding Aug 2026

Impact of hydrolyzed gelatin and hydroxypropyl-β-cyclodextrin as polymeric excipients on physical stability and injectability of high-concentration protein suspensions.

The current work highlighted the potential of polymer-based excipient systems for developing high-concentration injectable suspensions of proteins and their combinations on the viscosity, injectability, and stability.

Chanakya D. Patil, Yi-Jing Huang, K. Arte et al. · International journal of pha... · 0 citations