RNA Editing of DEGS1 Links Genetic Risk to Ceramide Dysregulation and Astrocyte Toxicity in ALS
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with ∼90% of cases being sporadic. Although genome-wide association studies have identified numerous genetic risk loci, these variants account for only a portion of ALS heritability, suggesting that additional genetic and regulatory mechanisms con...
Alan Guo, S. Lessard, Li-Lu Guo et al.
· bioRxiv · 0 citations