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Sponsored AI Networking Cookbook: Practical recipes for AI-assisted network automation and development AI Networking Cookbook: Practical recipes for AI-assisted network automation and development

Author

Riccardo Miggiano

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Open access Aug 2026

Structural and biophysical characterization of Mycobacterium tuberculosis DciA reveals functional convergence in DnaB helicase recognition

In bacteria, DnaB replicative helicases are essential for unwinding genomic DNA to provide the single‐stranded templates required for replication. The recruitment of the hexameric DnaB helicase to the origin of replication is mediated by distinct mechanisms that rely on specialized factors known as helicase loaders. Th...

Daniele Mazzoletti, Andrea Garavaglia, Hayden Fisher et al. · 0 citations
Open access Jul 2026

Discovery of a Dual IDO1/TDO Inhibitor That Modulates Enzymatic Activity and IDO1/SHP‑2 Signaling

Indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors have shown limited clinical translation, partly because IDO1 blockade can be bypassed by tryptophan 2,3-dioxygenase (TDO) and may stabilize nonenzymatic IDO1 signaling states that promote tumor progression. Here, we report compound 66, an ortho-benzamidourea derivative ob...

Sarah Jane Rezzi, Andrea Butticè, Salvatore Villani et al. · 0 citations

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