Author

Rolf Müller

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#protein folding Sep 2026

“Sex-divergent responses to microglial depletion suggest distinct regulatory dependencies in the aged brain”

Microglia are essential for brain homeostasis, yet their roles in the aged brain remain poorly defined. Using microRNA (miRNA) profiling, cellular-resolution spatial transcriptomics, and bulk proteomics in 21-month-old mice, we characterize sex-dimorphic responses to microglial depletion via CSF1R inhibition (PLX5622 t...

Amila Beganovic, M. Flotho, Jin-Xiu Li et al. · bioRxiv · 0 citations

Open access Aug 2026

Synthesis and Activity-Based Protein Profiling Identifies Aldo-Keto Reductase 1C3 as Target Protein of Myxoglucamides.

Myxoglucamides, natural products recently isolated from Cystobacterineae sp., are featured by an unprecedented vinyl-substituted α-keto-γ-amino acid that is linked to a glycosylated 14-methyl-pentadecanoic acid. Thus, they unite elements from three biomolecular classes in a compact glycolipopeptide. To elucidate the bi...

Thomas Siemon, Vivek K. Mishra, Mingming Zhao et al. · Angewandte Chemie · 0 citations