Author

Rolf Turk

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Open access Aug 2026

UNCOVERseq enables sensitive and controlled gene editing off-target nomination across CRISPR-Cas modalities and systems

An in-cell method that sensitively detects rare off-target edits, benchmarks performance across editors, and improves risk assessment in therapeutic cells is presented, establishing UNCOVERseq as a robust framework for informed off-target risk assessment in translational gene-editing systems.

Kyle J. Kinney, Kun Jia, He Zhang et al. · Nature Communications · 3 citations

Open access Aug 2026

CRISPR RNA architecture steers Cas9 catalysis and fidelity via a guide repeat clasp motif

A previously unknown mechanism that steers Cas9 catalysis is uncovered and the potential to improve Cas9 fidelity by modulating guide repeat interactions is demonstrated.

Ramadevi Chilamkurthy, Sruthi Sudhakar, Adrian A. Pater et al. · Nucleic Acids Research · 0 citations