Functional genetics reveals a role for the proteasome in regulating centromere assembly
Centromeres link chromosomes to spindle microtubules to direct their segregation during mitosis. The vertebrate centromere is built on two critical DNA-binding proteins, the histone H3-variant CENP-A and histone fold protein CENP-T. CENP-T is a potent scaffold for kinetochore assembly, such that concentrating it at ect...
Océane Marescal, Kuan-Chung Su, Matteo Di Bernardo et al.
· bioRxiv (Cold Spring Harbor... · 0 citations