ABSTRACT Acquired resistance to gemcitabine (GEM) remains a major barrier to effective treatment of pancreatic ductal adenocarcinoma (PDAC). Here we identify histone H3K18 lactylation (H3K18la), induced by GEM‐driven lactate accumulation, as a key epigenetic mechanism of chemoresistance. H3K18la functions as a transcri...
Li-Jun Zhao, Jian-Zhong Cao, Wen-Yue Liu et al.· Advancement of science· 0 citations
A modular biomarker framework integrating genomic, functional, immune‐context, spatial and dynamic readouts to guide patient selection, treatment adaptation, and precision therapeutic decision‐making is proposed.
Yi-Huan Qiao, B. Kang, Jian Zhang et al.· MedComm· 0 citations
This review systematically delineates the alterations in gut microbiota dysbiosis across various etiologies of cachexia and the functional roles of their related metabolites, and summarizes the mechanisms by which the gut microbiota regulates cachexia through the nervous system.
Ke Gao, Wen-Jin Xi, Yonghua Lei et al.· Molecular Aspects of Medicin...· 1 citation
It is found that the oncogenic effect of mutant p53 in vivo is dependent on the tumor immune microenvironment, and restoration of ALKBH5 activation or inhibition of the m6A modification-YTHDF3 axis could potentially reactivate immune surveillance and eliminate tumors harboring mut-p53.
