Author

Ryan M. Young

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#protein folding Open access Aug 2026

Phosphorylation Protects Oncogenic RAS from LZTR1-Mediated Degradation.

PAK1 and PAK2 shielded RAS from LZTR1-dependent degradation by phosphorylating T148, and inhibiting PAK1/2 activity improved RAS-directed therapy, revealing a regulatory circuit governing RAS stability that is preferentially active in blood cancers and potentially druggable.

Lin Zhang, A. Bolomsky, Omar S. Al-Odat et al. · Blood Cancer Discovery · 0 citations