Recent advances in molecular mechanisms to improve the efficacy of CAR-T cell therapy for viral diseases, cancer, and autoimmune diseases
This review synthesizes recent advances in molecular engineering strategies that enhance CAR-T cell function beyond conventional receptor design and discusses how receptor engineering, genome editing, transcriptional and epigenetic regulation, metabolic reprogramming, synthetic gene circuits, and safety-control platfor...
Hany E. Marei, G. Pozzoli, S. Caratelli et al.
· Stem cell research & therape... · 0 citations