Author

S. Claypool

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#gene editing Open access Sep 2026

Stoichiometric m6A regulation of YY1 orchestrates the metabolic switch during cardiac development

Chemical modifications of RNA provide an additional regulatory layer essential for development. N6A methyladenosine (m6A) is the most abundant internal mRNA mark, but how site specificity, stoichiometry, and cellular context together determine mRNA fate remains unclear. Here, we define these rules in cardiogenesis by c...

Shun-Yao Lei, H. Gangrade, Sheetal Bajpayi et al. · bioRxiv · 0 citations

Open access Aug 2026

Djp1 is a multifunctional Hsp40 cochaperone for mitochondrial phospholipid metabolism

It is demonstrated that Djp1 is a regulator of Phosphatidylserine decarboxylase 1 (Psd1), an inner mitochondrial membrane resident responsible for mitochondrial phosphatidylethanolamine production, and the combined loss of Djp1 and Psd1 results in a synthetic sick phenotype that unexpectedly reflects a role(s) for Djp1...

Rashima Prem, Alex Maya-Romero, C. Xie et al. · bioRxiv · 0 citations