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Oct 2026

Exploration of newly synthesized sulfonohydrazides as potential enzyme inhibitors: synthesis, characterization, and in silico studies.

AIM To synthesize novel sulfonohydrazide derivatives and evaluate their physicochemical and enzyme‑inhibitory profiles, together with the corresponding structure-activity relationships. METHODS A series of six hydrazide derivatives (NLs1-NLs6) was synthesized and subjected to comprehensive in vitro enzymatic evaluati...

Lubabah Abdul Karim, Amara Mumtaz, S. Ejaz et al. · 0 citations
#protein folding Open access Sep 2026

Design, synthesis and network pharmacology-integrated evaluation of benzenesulfonamides as potential Dickkopf-1 (Dkk-1)-targeting anticancer candidates

A network pharmacology analysis of compound 4d against pancreatic cancer identified 243 shared targets that converged, through protein-protein interactions and enrichment analyses, on the PI3K-AKT and receptor tyrosine kinase signalling axes, providing a system-level rationale for its anticancer potential.

S. Ejaz, M. Bilal, P. Channar et al. · 0 citations

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