Author

S. Heikkinen

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Open access Sep 2026

APOE-stratified genome-wide association analyses provide insights into the genetic etiology of Alzheimers's disease.

Understanding of the genetic architecture of AD in the context of its main genetic driver is improved, and APOE-stratified insights may help understand and overcome side effects, inform clinical trial enrollment strategies, and create the scientific basis for targeted, mechanism-driven therapies in neurodegenerative di...

J. Thomassen, H. Leonard, Brittany Ulms et al. · Nature Genetics · 0 citations

Open access Aug 2026

PLCG2 downregulation impairs synaptic function and increases Alzheimer’s disease hallmarks in neuronal cultures

It is demonstrated that downregulation of PLCG2, primarily in neurons, impairs synaptic function and elevates amyloid-β levels and Tau protein phosphorylation in neurons.

Audrey Coulon, F. Rabiller, M. Takalo et al. · Nature Genetics · 0 citations

Open access Aug 2026

C9orf72-associated and sporadic FTD patient iPSC-microglia show differences in phagocytosis and gene expression

Summary C9orf72 hexanucleotide repeat expansion (C9-HRE) is a major genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia (FTD). However, approximately half of the FTD patients are sporadic without a clear genetic background. To compare characteristics of microglia from different FTD subtypes, we g...

Hannah Rostalski, Tomi Hietanen, Dorit Hoffmann et al. · Stem Cell Reports · 1 citation