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#protein folding Oct 2026

Multiomics Profiling Supports Cathepsin B as a Protective Factor in White Matter Hyperintensities and Cognition.

BACKGROUND White matter hyperintensities (WMH) are a common brain magnetic resonance imaging marker of cerebral small vessel disease and a major risk factor for stroke and dementia, yet the molecular mechanisms governing lesion formation remain incompletely understood. We sought to identify circulating proteins that li...

C. Rivier, Sebastián Díaz-Pérez, Gael Bories et al. · 0 citations
Open access Sep 2026

Multi-trait Polygenic Profiling and Survival Free of Dementia and Disability: Results from the Health and Retirement Study

ABSTRACT Objective: To determine whether a multi-trait polygenic profile for dementia is associated with dementia- and disability-free survival in middle-aged and older adults. Background: Clinical trials of brain health and aging increasingly use holistic, patient-centered outcomes that capture overall health status....

Y. Tawaldemedhen, S. Clocchiatti-Tuozzo, C. Rivier et al. · 0 citations

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