Author

S. Leist

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Open access Aug 2026

Systems genetics analysis reveals immune mediators of coronavirus disease severity in mice

Abstract Severe disease following infection with SARS-CoV or SARS-CoV-2 is driven in part by genetically regulated immune responses that promote lung injury. To study genetic mechanisms of immune-mediated coronavirus pathogenesis, we screened the Collaborative Cross (CC) panel for Mus musculus strains that are phenotyp...

Ellen L. Risemberg, S. Leist, A. Schäfer et al. · Genetics · 0 citations

Aug 2026

Convergent IGHV3-53/3-66 antibodies elicited by Omicron BA.1 infection broadly neutralize emerging SARS-CoV-2 variants

G germline revertant analysis of the COV2-3731 mAb provided additional insights into how this COV2-3731 and other IGHV3-53/3-66-encoded public antibodies evolve to gain breadth against antigenically distinct SARS-CoV-2 variants such as BA.2.3.2, BA.3.1, KP.2.2, and, to some extent, KP.3.3.2.

Naveenchandra Suryadevara, Seth J. Zost, John M. Powers et al. · bioRxiv · 0 citations