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Convergent IGHV3-53/3-66 antibodies elicited by Omicron BA.1 infection broadly neutralize emerging SARS-CoV-2 variants

Naveenchandra Suryadevara Seth J. Zost John M. Powers Bernadeta Dadonaite P. Gilchuk E. Binshtein S. Scheaffer S. Leist Luke Myers S. Ravera Lily E. Adams Laura S. Handal Shruthi Kannan E. Davidson Benjamin J. Doranz Andrew Trivette M. Abney Doan C. Nguyen F. E. Lee Robert H. Carnahan Jesse D. Bloom R. Baric Michael S. Diamond James E. Crowe
Aug 2026 · bioRxiv · 0 citations
Biology

TL;DR

G germline revertant analysis of the COV2-3731 mAb provided additional insights into how this COV2-3731 and other IGHV3-53/3-66-encoded public antibodies evolve to gain breadth against antigenically distinct SARS-CoV-2 variants such as BA.2.3.2, BA.3.1, KP.2.2, and, to some extent, KP.3.3.2.

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