S. Mohammad

Mitochondria-Centered Metabolic Microdomains: Regulatory Roles in Synaptic Plasticity and Circuit Homeostasis.

The metabolism of neuronal activity is highly localized and cannot be sustained by cell-wide distribution of energy. Neurons and glia organize metabolic enzymes, mitochondria, lipid droplets, and endoplasmic reticulum (ER) contacts into spatially localized microdomains that dynamically couple energy generation to synap...

NRF2-Regulated Ferroptosis in Breast Cancer: Mechanisms, Resistance, and Therapeutic Opportunities.

Breast cancer remains a significant clinical challenge, particularly in triple‑negative breast cancer (TNBC), in which therapeutic resistance limits treatment efficacy. Ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation, has emerged as a promising strategy to overcome resistance in...

AEG-1/MTDH: A central regulator of tumor progression, metabolic adaptation, and therapeutic resistance in gliomas.

Astrocyte-elevated gene-1 (AEG-1), also known as metadherin (MTDH), is a pleiotropic oncogene critically involved in the onset and development of glioblastoma (GBM), other malignant gliomas, and neuroblastoma. Its expression is upregulated under hypoxic conditions and during glucose deprivation, enabling tumor cells to...

Deep ANN feature fusion with multi-stage data processing and visualization for enhanced breast cancer detection in ultrasound images

A major obstacle to breast cancer detection in ultrasound images is that they can be difficult to evaluate due to speckle noise and low contrast as well as very subtle differences between the appearance of benign vs. malignant lesions. With the advent of large amounts of digital medical imaging, particularly ultrasound...

Circular economy models in biotechnology: waste-to-resource pathways for biodiversity enhancement

Abstract The transitional shift from a linear production-consumption-disposal model towards a circular economy model leads to ecosystem pressure reduction while maintaining biodiversity protection. This study develops and assesses waste-to-resource biotechnology systems to determine their impact on biodiversity conserv...

The mediating role of green innovation capability between AI-driven green project management and sustainable project performance including MADANI sustainability in Malaysian green projects

Artificial intelligence has become a core enabling factor for raising the standard of sustainable project management, and it can effectively strengthen organizational capacity, innovation levels, and the quality of environmental decision-making. Against this backdrop, this study is an original empirical study focused o...

Extracellular Vesicles in Neurodegenerative Diseases: A New Frontier in Diagnosis and Therapy.

Neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and Huntington's disease are among the progressive disorders of the nervous system that are characterized by the gradual destruction of neurons, the accumulation of misfolded proteins, and the limited effectiv...

Condition-based maintenance threshold determination for gearbox fault progression using vibration envelope features and accelerated life testing

Gearbox failures represent a critical problem faced by industrial machines, considering the impacts of such failures on machine reliability, efficiency, and maintenance cost. Despite the well-established use of vibration-based condition monitoring techniques for diagnosing the presence of faults, few attempts have been...

Net sustainability assessment of AI-driven data centers in the GCC: an MCDA approach framework

The Gulf Cooperation Council (GCC) is witnessing a rapid growth in artificial intelligence (AI)-enabled data center development, thanks to national digital transformation strategies and the region’s strategic location bridging global markets. Yet, no evaluation framework holistically compares the direct impacts of data...

AI-Powered Assessment in Physical Education: Rethinking Student Engagement through Social Sciences Perspectives First position