Author

S. Pinglay

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#gene editing Open access Oct 2026

Multiplex programming of mappable, molecularly tagged genomic deletions

Conventional CRISPR knockout screens target genes via focal indels that readily disrupt open reading frames (ORFs). However, their utility for targeting candidate cis-regulatory elements remains limited, as focal indels cannot abrogate enhancer activity with high confidence. Compounding this limitation, conventional CR...

Aidan Keith, R. Daza, Jonas Koeppel et al. · bioRxiv · 0 citations

Open access Oct 2026

Highly multiplexed mammalian metabolic engineering with a shotgun approach.

Mammalian metabolic engineering advances basic biology, bioproduction and cell therapy. However, as pathway complexity increases, so does the size of the combinatorial design space and required DNA constructs, rendering unbiased screens intractable. Here, we developed shotgun genetic engineering (SGE), which exploits t...

Julie Trolle, Sofia Sessa, A. Wudzinska et al. · Nature Biotechnology · 1 citation