S. Riedel-Heller

Obesity and poor sleep quality – prevalences and risk factors from the LIFE-Adult-Study

Research has linked obesity to poor sleep. Yet, comprehensive large-scale studies are lacking. This study provides prevalence estimates of poor sleep quality among individuals with obesity and associated risk factors. The study sample comprised 1,416 individuals with obesity from the German population-based LIFE-Adult-...

Examining the Contribution of Childhood Maltreatment to the Sex Gap in Depression: Insights from the German National Cohort (NAKO).

APOE-stratified genome-wide association analyses provide insights into the genetic etiology of Alzheimers's disease.

Understanding of the genetic architecture of AD in the context of its main genetic driver is improved, and APOE-stratified insights may help understand and overcome side effects, inform clinical trial enrollment strategies, and create the scientific basis for targeted, mechanism-driven therapies in neurodegenerative di...

Modifizierbare Risiko- und Schutzfaktoren für Demenz: Etablierte und neue Evidenz im Überblick

Die Alzheimer-Erkrankung und andere Formen von Demenz zählen zu den schwerwiegenden Volkskrankheiten, deren gesellschaftliche und gesundheitssystemische Bedeutung in den kommenden Jahren weiter zunehmen wird. Prognosen zur Krankheitslast sind entsprechend besorgniserregend. Gleichzeitig wurden in der Forschung, insbeso...

Exome analysis of 22,319 individuals links extremely rare copy-number variants and 22q11.21 dosage to Alzheimer risk.

It is concluded that rare coding CNVs in a proportion of AD-associated genes and 22q11.21 duplication as a strong AD-risk-decreasing factor increase AD risk and Conversely, 22q11.21 duplication as a strong AD-risk-decreasing factor is identified.