Author

S. Schwartz

3 papers indexed here

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Sep 2026

Phosphate backbone epitranscriptomics: Discovery of natural RNA phosphorothioates and their writer machinery.

Over 150 modifications expand the RNA alphabet, yet all known natural modifications occur on nucleobases or ribose sugars, with none identified on the phosphate backbone. In contrast, phosphorothioates (PSs), in which a non-bridging phosphate oxygen is replaced with sulfur, are central to RNA therapeutics but have neve...

Alexander Maman, Yuko Nobe, K. Fluke et al. · Cell · 0 citations

Open access Aug 2026

The pseudouridine synthase PUSL1 modifies U39 of mitochondrial tRNAs and is linked to human neurological phenotypes

Abstract Variants in the mitochondrial and nuclear genomes are linked to a wide range of human disorders marked by impaired mitochondrial function. Among these disorders, there is a growing number of patients with variants affecting mitochondrial RNA biology. Mitochondrial transcripts are pseudouridylated, and some enz...

Pedro Rebelo-Guiomar, Nadav Kra-Oz, Christopher A. Powell et al. · Nucleic Acids Research · 0 citations

Open access Aug 2026

RTTN moonlights beyond the centrosome to control ribosome biogenesis and tRNA modification in human brain organoids

It is shown that RTTN has an unrecognized function at the core of the translation machinery and is enriched in cycling first-trimester neural progenitors and physically associates with ribosome-biogenesis and RNA-processing factors.

A. Hadar, K. Draganova, V. Iyer et al. · bioRxiv · 0 citations