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RTTN moonlights beyond the centrosome to control ribosome biogenesis and tRNA modification in human brain organoids

A. Hadar K. Draganova V. Iyer B. Bhattacharya Y. Komemy Alfredo-Isaac Ponce-Arias L. Otikovs I. Vaknin N. Dezorella L. Wilk A. Lilja S. Doroshev T. Olender M. Danan-Gotthold J. Fu J. Merl-Pham E. Rusha R. Gabarró-Solanas A. Flatley H. Zitzelsberger R. Feederle Stefanie M. Hauck S. Schwartz M. Götz O. Reiner
Aug 2026 · bioRxiv · 0 citations · 35 references
Biology

TL;DR

It is shown that RTTN has an unrecognized function at the core of the translation machinery and is enriched in cycling first-trimester neural progenitors and physically associates with ribosome-biogenesis and RNA-processing factors.

DOI Semantic Scholar
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