Design, synthesis, and evaluation of pyrano[3,2-c]coumarin derivatives for simultaneous targeting of amyloid-β42 and acetylcholinesterase in transgenic AD model of Drosophila
The design, synthesis, and biological evaluation of a novel series of pyrano[3,2-c]coumarin derivatives 4a–n as dual Aβ42 and acetylcholinesterase (AChE) targeting anti-AD agents are described.