T2D like model was established by inducing insulin resistance through knockdown of the insulin receptor in brain insulin-producing cells using the dilp2-Gal4>UAS-InRRNAisystem, which resulted in significant metabolic dysregulation, including elevated glucose, trehalose, and triacylglyceride levels, along with increased oxidative stress indicators.
This study illustrated that nomilin alleviated insulin resistance via activation of PI3K/Akt/GLUT4 signaling pathways, alleviating ROS accumulation and damage, and AGEs production, and improving the mitochondrial function.
Jin-Can Luo, Jin-Hai Luo, Bin-Cheng Han et al.· Food Science and Human Welln...· 0 citations
Diabetes mellitus (diabetes) is a major health burden with the highest mortality rate, affecting an estimated 537 million adults worldwide. The treatment of diabetes remains complex owing to insulin resistance, β-cell dysfunction, metabolic inflammation, and progressive organ damage. While G-protein-coupled receptors (...
Sureka Chandrabose, Vikraman Muniyandi, Ayman Geddawy et al.· Frontiers in Endocrinology· 0 citations
FHT mitigates podocyte injury by reshaping lipid metabolic homeostasis via multiple targets, providing a strong mechanistic basis for its clinical use in NS.
Z. Xue, Meng-Jiao Wang, Ting Linghu et al.· Journal of chromatography. B...· 0 citations
Diabetes mellitus and cancer are among the most prevalent chronic diseases worldwide, and accumulating evidence suggests a significant association between these conditions. The metabolic disturbances characteristic of diabetes, including hyperglycemia, hyperinsulinemia, insulin resistance, and chronic inflammation, cre...
Nahed S. Alharthi· American Journal of Cancer R...· 0 citations
Obesity and type 2 diabetes (T2D) represent a major globalhealth burden, with increasing prevalence linked to sedentary lifestyles, poor dietary habits, and genetic predisposition. These conditions are strongly interconnected through a range of metabolic dysfunctions, including insulin resistance, chronic inflammation,...
Nakawungu Catherine· IDOSR JOURNAL OF EXPERIMENTA...· 0 citations
Statins are a commonly prescribed cholesterol-lowering drug class that can increase the risk of new-onset diabetes (NOD). The underlying molecular mechanisms have yet to be fully elucidated. We aimed to identify molecular factors associated with differential susceptibility to NOD and determine their effects on β-...
Yu-Lin Kuang, C. Locatelli, Yu-Qing Zhang et al.· Cardiovascular Diabetology· 0 citations
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