Background and Objectives Adults with Down syndrome (DS) have an increased risk of developing early Alzheimer disease. While our previous cross-sectional study investigated the blood proteome in the context of Alzheimer in DS, identifying CBLN4, CD14, C-X-C motif chemokine 17 (CXCL17), ectodysplasin A2 receptor (EDA2R)...
Olivia Wagemann, Georg S. Nuebling, K. Sandkühler et al.· Neurology· 0 citations
Patients with Alzheimer’s disease (AD) and clinically overlapping neurodegenerative diseases are classified molecularly using the A/T/N classification system. Apart from fluid biomarkers and structural MRI, A/T/N assessment incorporates β-amyloid-PET (A), tau-PET (T), and [18F]FDG-PET (N). We evaluated if dynamic featu...
Johannes S. Gnörich, J. Kusche-Palenga, Agnes Kling et al.· Molecular Neurodegeneration· 0 citations
Ongoing research aims to establish sensitive biomarkers, identify prodromal disease stages, and develop targeted interventions addressing key pathophysiological mechanisms such as α-synuclein aggregation and neuroinflammation.
I. Wilkens, Sabrina Katzdobler, A. Bernhardt et al.· Fortschritte der Neurologie...· 1 citation
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