Author

Sanjaya C. Abeysirigunawardena

2 papers indexed here

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Open access Sep 2026

RNA-Binding Peptide Influences Epitranscriptomic Regulation by Preferentially Binding to Unmodified RNAs Targeted by NSUN2

5-Methylcytosine (m5C) is a widespread mRNA modification that regulates gene expression and is frequently dysregulated in cancer. Here, we used phage display to identify peptides that bind an NSUN2 consensus RNA sequence in either its unmodified (UN2-RNA) or m5C-modified (MN2-RNA) form. A single peptide, un2p1 (TDYSTHR...

Chathurani Ekanayake, Aftab Mollah, Maelee Thompson et al. · Biomolecules · 0 citations

#protein folding Open access Sep 2026

N6-Methyladenosine RNA Modifications Influence the Stability of FUS-Dependent Biological Condensate Formation

Liquid–liquid phase separation (LLPS) is a process in which proteins and nucleic acids organize into dynamic, membrane-less structures within cells. These structures help regulate cellular processes such as gene expression, molecular storage, and stress responses through weak interactions between disordered protein r...

Chamali Thalagaha Mudiyanselage, Milan Pandey, Sudeshi M. Abedeera et al. · ACS Bio & Med Chem Au · 0 citations