Author

Scott R. Kennedy

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Open access Sep 2026

Temporal control of mitochondrial mutagenesis reveals the fate of mtDNA mutations with age

Mutations in the mitochondrial genome (mtDNA) play a critical role in the aging process and a wide variety of age-related diseases. However, it remains unclear when the mutations that drive physiological decline arise. To answer this question, we generated a new mouse model in which mitochondrial mutagenesis can be con...

Sarah J. Shemtov, Eric Hwang, Claire S. Chung et al. · bioRxiv · 0 citations

Open access Aug 2026

‘An NF2-wildtype malignant meningioma cell line for basic and translational science’

Background Meningiomas are the most common primary nervous system neoplasm in adults. There are few good cellular models, especially of high grade/malignant meningiomas, to use to identify new therapeutic agents and treatment regimens. The widely available, partially characterized, NF2-wildtype (NF2wt) Grade 3 malignan...

Perry Chien, Brendan F. Kohrn, Megan M. Nguyen et al. · bioRxiv · 0 citations

#protein folding Open access Sep 2026

Single nucleus RNA sequencing and spatial transcriptomics reveal unique functionalities of gray matter versus white matter oligodendrocytes in aging and Alzheimer’s Disease

This analysis identified a conserved newly formed differentiating (NFOL)/differentiating → lipid remodeling → Stress/ISR-reactive architecture, with a pronounced expansion of the Stress/ISR-reactive compartment and altered transition-associated pathway enrichment in high ADNC WM.

Joseph P. Voth, Javier Ramos Benitez, Angela M. Wilson et al. · bioRxiv · 0 citations