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Author

Sean A. Misek

2 papers indexed here

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Open access Aug 2026

O-mannosylation and furin processing are critical maturation events for the KIAA1549 protein implicated in pediatric pilocytic astrocytomas.

The gene fusion KIAA1549::BRAF is a common oncogenic driver in pediatric pilocytic astrocytoma. The chimeric fusion protein that comprises most of the type 1 transmembrane KIAA1549 protein fused in its C-terminal cytosolic domain to the truncated BRAF oncogene without its N-terminal autoinhibitory domains. KIAA1549 has...

Gloria Kyrila, Serpil Ahmed, Anna Borgenvik et al. · 0 citations
Open access Aug 2026

A compendium of next-generation patient-derived models for diverse cancers

The development of new therapeutics and the validation of pathogenetic cancer mechanisms require representative laboratory models1,2. However, existing collections represent only a fraction of the diversity observed in human cancer2, 3–4. Recent technologies have enabled efficient in vitro model derivation (for example...

Dina Elharouni, Mushriq Al-Jazrawe, Seongmin Choi et al. · 3 citations

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