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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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Sebastien Ghent

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Open access Oct 2026

AlphaFold3 and Intrinsically Disordered Proteins: Reliable Monomer Prediction, Unpredictable Multimer Performance

AlphaFold3 represents a major advance in protein structure prediction, yet its performance on intrinsically disordered proteins remains uncharacterized. We present the first systematic evaluation of AF3 on disordered systems, revealing a striking dichotomy. For monomers, AF3’s pLDDT scores reliably predict disorder (MC...

Tuan Minh Dao, Sebastien Ghent, Vladmir N. Uversky et al. · 4 citations
#protein folding Open access Oct 2026

AlphaFold3 and Intrinsically Disordered Proteins: Reliable Monomer Prediction, Unpredictable Multimer Performance.

These findings establish AF3 as reliable for the prediction of monomer disorder but unpredictable for multimers, confirming that disorder prediction emerges from training data, not model design.

Tuan Minh Dao, Sebastien Ghent, Vladmir N. Uversky et al. · 0 citations

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