A novel minimally humanized mouse model of aniridia for preclinical evaluation of CRISPR gene editing strategies
A minimally humanized mouse model of aniridia, carrying a FLAG-tagged Pax6 and the most common recurring pathogenic aniridia-patient variant, introduced for the first time in mice is generated and tested, supporting successful generation and phenotypic validation of the humanized mouse.
Seyedeh Zeinab Mirjalili Mohanna, Andrea J. Korecki, Pardis Kazemian et al.
· Frontiers in Genome Editing · 0 citations