Author

Shameer Khader

2 papers indexed here

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Review Open access Sep 2026

Pathway-driven target prioritisation in drug discovery.

Genome-scale association studies and functional screens routinely implicate hundreds of candidate genes per disease, yet only a few will be clinically validated as drug targets. Choosing which to pursue is a central drug-discovery decision that depends on interpreting each candidate in its biological context. Curated p...

Polina Rusina, D. Ochoa, Franck Rapaport et al. · Drug Discovery Today · 0 citations

#gene editing Open access Sep 2026

RNA Editing of DEGS1 Links Genetic Risk to Ceramide Dysregulation and Astrocyte Toxicity in ALS

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with ∼90% of cases being sporadic. Although genome-wide association studies have identified numerous genetic risk loci, these variants account for only a portion of ALS heritability, suggesting that additional genetic and regulatory mechanisms con...

Alan Guo, S. Lessard, Li-Lu Guo et al. · bioRxiv · 0 citations