Comparative Analysis of Choroid Plexus Volume Between MOG Antibody Associated Disease and Multiple Sclerosis
ABSTRACT Choroid plexus volume (CPV) has been proposed as a neuro‐immunological marker of multiple sclerosis (MS), but its relevance in myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD) remains uncertain. We analyzed CPV in 43 individuals with MOGAD, 48 with MS, and 44 healthy controls using a Bayesian Gaussian mixture modeling applied to 3D‐T1‐weighted‐MRI. Total intracranial volume‐normalized CPV did not differ between MOGAD and healthy controls, whereas the MS demonstrated significantly higher values than both groups (p < 0.001) and showed associations with clinical disability. These findings suggest relative preservation of CPV in MOGAD and support a closer association of CPV enlargement with disease‐related structural changes in MS than in MOGAD.